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Objective: The regenerative potential of bone marrow-derived mononuclear cells [MNCs] and CD133+ stem cells in the heart varies in terms of their pro-angiogenic effects. This phase II/III, multicenter and double-blind trial is designed to compare the functional effects of intramyocardial autologous transplantation of both cell types and placebo in patients with recent myocardial infarction [RMI] post-coronary artery bypass graft
Materials and Methods: This was a phase II/III, randomized, double-blind, placebo-controlled trial COMPARE CPM-RMI [CD133, Placebo, MNCs - recent myocardial infarction] conducted in accordance with the Declaration of Helsinki that assessed the safety and efficacy of CD133 and MNCs compared to placebo in patients with RMI. We randomly assigned 77 eligible RMI patients selected from 5 hospitals to receive CD133+ cells, MNC, or a placebo. Patients underwent gated single photon emission computed tomography assessments at 6 and 18 months post-intramyocardial transplantation. We tested the normally distributed efficacy outcomes with a mixed analysis of variance model that used the entire data set of baseline and between-group comparisons as well as within subject [time] and group×time interaction terms
Results: There were no related serious adverse events reported. The intramyocardial transplantation of both cell types increased left ventricular ejection fraction by 9% [95% confidence intervals [CI]: 2.14% to 15.78%, P=0.01] and improved decreased systolic wall thickening by -3.7 [95% CI: -7.07 to -0.42, P=0.03]. The CD133 group showed significantly decreased non-viable segments by 75% [P=0.001] compared to the placebo and 60% [P=0.01] compared to the MNC group. We observed this improvement at both the 6- and 18-month time points
Conclusion: Intramyocardial injections of CD133+ cells or MNCs appeared to be safe and efficient with superiority of CD133+ cells for patients with RMI. Although the sample size precluded a definitive statement about clinical outcomes, these results have provided the basis for larger studies to confirm definitive evidence about the efficacy of these cell types
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Objective: Numerous studies have emphasized on the importance of developing an ideal educational system for high-quality dental education. The present study sought to assess the perception of dental students on operative dentistry education in Department of Restorative Dentistry, Shahid Beheshti Dental School, Tehran, Iran
Methods: In this descriptive cross-sectional study, 220 students were selected and given a questionnaire including demographic , grades in operative dentistry clinical and didactic courses, the efficacy of preclinical courses in preparing students for clinical practice, ways to improve competency and expertise of students for clinical setting, student's opinion on relating the assessment tests with the taught topics, required instructional resources for assessment of students' proficiency in restorative dentistry and satisfaction rate of students with clinical courses offered in the current curriculum. Data were analyzed using descriptive statistics [SPSS 18]
Results: The Clinical Operative Dentistry 3 and Preclinical Dental Anatomy received a mean satisfaction score of 3.31 and 2.74, respectively. Furthermore, 57.3% of students highly emphasized the necessity of studying textbooks of restorative dentistry. 50.5% of students believe that lectures by instructors along with active participation of students were the best method for didactic operative dentistry courses. In addition, 60.5% were in favor of using a combination of textbooks, lectures, and class notes for the assessment of students' learning
Conclusion: The present study revealed that Department of Restorative Dentistry in Shahid Beheshti Dental School is successful in its teaching and achieving students' satisfaction. However, some revisions need to be made in educational methods and contents and active participation of students in class discussions should be encouraged as well
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The human blood basal glucose level is a completely controlled range. Information on the relationship between culture glucose concentration and changes in the cell's surface area, volume and surface area to volume [S/V] ratio are lacking. Cancerous epithelial-like cell lines SW480, SW742 and T-47D were cultured in mediums nourished with 4.7 mM per liter of glucose as the control group and three other groups with glucose concentrations of 9.4, 14.1 and 18.8 mM at 37[degree]C for 48hr. Digital images of cells were analyzed using the Image J software. Observed changes in surface area, volume, and surface area to volume [S/V] ratio were significantly [P<0.05] different between the control group and the X4 group [18.8 mM glucose] in the three cell lines tested. Cultured cells responded delicately but sharply to glucose elevation. The goal of this research is to show the dictating of changes via pathologic conditions in cellular levels that could be a good answer to changing the body metabolic parameters. Besides the S/V ratio could be studied as a variant parameter in other metabolic challenges
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Conceptualization for new findings is the main aim of science and technology development. Sometimes new concepts are pathfinders for science and starting fundamental revolutions in science. An important area in scientology or scientific studies is the concept and term field, so terminology and its effect on science and technology is one of the most important subjects in the last decade. Standardization in scientific terms [scientific term selection] is one of the strongest terminology methods. These methods break down the terms to their meaningful parts or use prevalent terms, which are common among people or use eponyms and abbreviation processes, and finds the appropriate equivalent for them. The word parts are prefixes, suffixes and stems. In medical sciences, terms are mostly originated from Latin stems, so this method could be extremely efficient in these fields. The terminology committee of Persian Academy studied the highly frequent prefixes, suffixes and stems to help the standardization of terminology in medical sciences. This research introduces methods of term selection, some approved terms and their Persian equivalents. Term selection for medical terms is not an obligatory rule, but is a proposal for meeting the researchers need to strength Persian language as a scientific language